It's a balancing act for me between comfort, looks and functionality. I'm sure Strats are comfortable but I hate the look (reminds me of Bryan Adams). First time I played a Les Paul I couldn't believe how much I DIDN'T like it. It felt horribly chunky.
I've got three electrics at the moment (arguably too many). My Ibanez RG421 is unbelievably playable. I bought it in a shop and it was immediately great. I kind of messed it up by replacing the bridge (NEVER get Cosmo Chrome, it tarnishes quick so I replaced it with black) but then I got dead frets. So I had it adjusted by a pro guy near me and it's now basically playing itself.
My HB Tele has a bit more resistance but my favourite. Teles don't give you anything for free. But this one has a trem, so it's basically perfect. The Tele shape is good looking and very comfy.
I've also got a 335 copy. I've always loved that shape. Very comfortable body but a bit large. I'm mostly a sofa player now.