I know exactly what you mean. I have a lovely LP junior type with lipstick pickups. I love the sound of it for almost everything, but some things don't work under my fingers on it. But grab the StratoTele (in my avatar) and all fits into place for some reason. And the same in reverse. Must be something subtle about the size of the neck, the radius, scale length that just suits some tracks and not others. Although I have to say that the StratoTele covers far more bases than any of my others. If it had to be one it would be that one.