These don't sound, to me, the most appropriate for a Strat, at least for obtaining the more typical Strat tones. A set of ordinary light 10-46 would be my starting point (I'm not particularly fussy about make, or even gauge, normally; this is just the String 101 suggestion...). Those flat-wounds would certainly produce 'better' jazz vamping tones, and would sit well on many of my arch-tops; a Strat would be good with them on, but not for 'typical' Strat tones, is all. Put a set of Ernie Ball Light on, to try..? These will require a quite different 'touch', compared to flat-wounds, so right-hand technique should be adapted as a consequence. Any help..?
(Disclaimer : apart from being a drummer, my guitar playing is very limited, and much more suited to fake 'jazz' stuff. Liquid runs à la Steve Vai are far from my repertoire. On the other hand, Our Eldest plays well, but not on Strats specifically...)