Only with a Kemper. If I'm honest, the Kemper profiles actually sounded better when they were created in a top quality setting. Less noise. My set up is pretty simple, I only use pedals in the effects loop and there's no discernable difference in quality with or without the pedal (Line 6 M5). It seems like you have a fairly specific set up and might need to dig into settings and work out what's happening through a process of elimination - if that's possible.